Wellcome Trust Sanger Institute

Published on 11 years ago

Location: UK

Wellcome Trust Sanger Institute

Senior Programmer
Wellcome Trust Sanger Institute

Salary range is £29,750 to £37,525 per annum dependent on experience.

A Senior Programmer post is available in the Annotools Team to develop genome annotation software. This software is the main tool for much of the manual sequence annotation that takes place at the Sanger Institute (and collaborators in many laboratories across the world). Manual annotation is a core part of the Sanger Institute’s strategy for investigation of model organisms, human variation, pathogens and much more. A key part of annotation is to exploit the new sequencing technologies that have emerged over the last few years that have given new avenues for research into variation whether that is within a gene or between individuals and species. These new technologies present problems for annotation software in producing vastly more
data that must be made available to the annotator in a meaningful but very efficient way.

The post is to work on ZMap, a GUI-based multi-threaded application which is written in C for performance reasons and makes substantial use of Open Source software packages. This is principally a programming position and requires a high level of skill in C or C++. An applicant must have an ability to work on their own and investigate new software packages and data formats and standards for genome annotation as appropriate. They must be able to work on existing code and use software tools to help them analyse and modify that code effectively. They must be able to communicate with users to gather requirements for new features and to solve users problems. While bioinformatics experience is not essential it will be an advantage.

Essential Skills
High level skills in C and/or C++
Experience in GUI and event-driven programming
Be able to write thread-safe code in a Posix environment
Proven record of computer program design and implementation in C or C++
Ability to quickly adapt to new problems and ideas
Able to modify, extend and improve existing code
Ability to effectively communicate directly with users

Ideal Skills
Good BSc, PhD or equivalent experience in computer science/programming
Experience with GUI programming in the X Windows environment (e.g. GTK+)
Experience in bioinformatics/genomics
Experience with C and MySQL
Some experience in perl, shell and autoconf
Some experience of simple html/xml

Other information: The Wellcome Trust Sanger Institute is a world leader in genome sequencing and bioinformatics. Genome annotation is a core activity of the institute and the tools developed by the Annotools team are heavily used both at Sanger and in other laboratories around the world. We are seeking to improve these tools to make a significant improvement in the rate of annotation. There will be opportunities to attend conferences, work with other laboratories and to publish in journals.

For further details about this post please contact

When applying please submit a CV together with a covering letter explaining why you have applied for the post and why you think are a suitable candidate. To apply online for this role please select the APPLY button below.

This position is a permanent core-funded appointment and the Closing date is 22nd March 2013

Wellcome Trust Sanger Institute

Postdoctoral Fellow in Statistical Genetics – 81388

Wellcome Trust Sanger Institute

Salary range from £29,388 to £36,840 with a discretionary range to £39,721 per annum.

We are looking for a postdoctoral Statistical Geneticist to join the Podoconiosis Genetics Project; a collaboration between the Wellcome Trust Sanger Institute, Brighton and Sussex Medical School, the University of Buea (Cameroon), the Armauer Hansen Research Institute (Ethiopia) and the Center for Genomics and Global Health, National Human Genome Research Institute, NIH (USA).

Funded by a MRC project grant, the role involves analysing whole-genome and whole exome sequence data from case-control cohorts from different African populations affected by podoconiosis (non-filarial elephantiasis, a neglected tropical disease caused by irritant clay soils in genetically predisposed individuals, see www.podo.org for more information). We are looking for a candidate with a strong record of academic achievement including a relevant degree. Good programming and statistical skills are essential as is experience of working with large-scale genetic data. Excellent facilities are available and there is a strong commitment to career development.

Essential Skills

  • Experience in quantitative science or life sciences as evidenced for example by a postgraduate degree in a relevant subject (e.g. Statistics, Computing, Genetics);
  • Research experience in linking whole-genome and/or whole exome sequencing data with phenotypes of interest;
  • Good scripting/programming skills;
  • Firm grounding in statistical methods;
  • Previous experience in working with large-scale datasets;
  • Demonstrable good project management and organisational skills;
  • Attention to detail and ability to work to tight timelines;
  • English language well-written and fluently spoken;
  • Ability to communicate effectively with collaborators both internally and externally.

Ideal Skills

  • Emerging track record of high-quality publications in reputable journals and other appropriate media of similar standing;
  • Experience in the preparation of grant applications;
  • Experience of supervising junior members of the team;
  • Understanding of the human immune system and its role in disease;
  • Familiarity with molecular biology and genetics techniques

Other information: Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award to be confirmed will be placed on a transitional pay point, currently £27,000. On confirmation applicants will be moved on to the pay range above.
This position is fixed-term for 3 years.

Closing Date: 22nd March 2013
To apply online for this role please select the APPLY button below.

Wellcome Trust Sanger Institute

Advanced Research Assistant – Genomic mutation and genetic disease
Wellcome Trust Sanger Institute

Salary range is up to £21,485 to £28,489 pa dependent on experience.
Job Reference: 81366

We are looking to recruit an enthusiastic and resourceful Advanced Research Assistant to join our exciting programme of research.

This programme involves using animal models to understand rare disease genetics in humans with the day to day activities of the role focusing on molecular biology laboratory work, such as DNA and RNA isolation, cloning, and immunohistochemistry. In addition there will be involvement in the handling, generation and analysis of zebrafish and mouse mutant and transgenic lines.

Essential Skills: The successful candidate will hold a BSc or have equivalent experience in the biological sciences with good background knowledge of molecular biology and genetics. In depth practical experience in relevant molecular biology techniques is also required. We are looking for a self-motivated individual who will be able to plan and prioritise their own day-to-day workload in order to solve existing and arising experimental problems. Applicants must be highly organised with strong attention to detail and possess good communication skills.

Ideal Skills: Practical experience in zebrafish or mouse embryology, genetics and husbandry would be advantageous.

Other information: The Genomic mutation and genetic disease group aims to understand the genetics underlying rare developmental disorders in humans. We have a number of sequencing projects currently underway identifying genetic changes in affected patients. To further our understanding of disease causes and mechanisms, we are generating animal models of the identified mutations and we are currently employing a number of approaches to create and analyse these animal models.

The appointed applicant will work under a Senior Staff Scientist in the team, generating essential tools for the animal and cell biology work, and will participate in the analysis of the resulting models.

Closing date: 16th February 2013

To apply for this position please click the APPLY button below.